“To estimate the peculiarities of hormonal and metabolic deviations in menstrual function disorders in adolescent girls with excessive and insufficient body weight”
(research supervisor – Doctor of Medical Sciences, professor S.O. Levenets, 2007−2009 yrs)
Deviations in the BMI from the optimal indices have been registered in adolescent girls, aged 13–17, with menstrual function disorders more often than in their coevals in the population, irrespective of clinical variant of the pathology.
Object of study: menstrual function disorders (MFD) in adolescent girls against the background of body weight (BW) deficiency or excess.
Objective: raising the effectiveness of treating adolescent girls with MFD on the basis of determining hormonal and metabolic peculiarities and the blood supply rate of internal genital organs at said disorders against the background of deficient or excessive body weight.
Methods: clinico-paraclinical, including instrumental ones, radioisotope, immunofermental, and biochemical.
Theoretical and practical results: it was established that in adolescent girls with MFD BW deficiency or excess were registered more frequently that in population. Most of hormonal and metabolic findings in adolescents with MFD depended both on clinical variants of the pathology and on BMI. It was shown that the dependence between hormonal and metabolic status in the girls differed significantly from that in women of fertile age. It was also established that in adolescent girls with BW deficiency MFD occurred usually against the background of the sexual system infantile functioning. Insulin resistance (IR) was proved to take place not only at BW excess but also at its deficiency, and also when BW corresponded to age. It was revealed that only a part of insulinresistant adolescents (17 %) had dyslipidemia of atherogenic character. In adolescents with normal BMI hypoleptinemia was quite often revealed (29–78 %). On the basis of the results obtained new nonhormonal treatment complexes were proposed, and two of them were tested, their effectiveness amounting to 72–75 %.
Novelty: there was shown a dependence of hormonal and metabolic status in adolescent girls with MFD on BW, and also the possibility of hypoleptinemia impact on MFD development in adolescent girls with normal BW. Nonhormonal methods were adjusted for treating adolescents with MFD.
Effectiveness: rise of effectiveness (up to 72-75 %) of treating adolescent girls with MFD against the background of BW deficiency or excess as a result of employing novel nonhormonal treatment complexes.
Field of application: pediatric gynecology.
